Product on VINCIT LifeSciences
Vincit LifeSciences offers world class products and services for various critical illness and diseases. At Vincit LifeSciences, our purpose is to improve the quality of life of the communities we serve.
The products that fall in the Allergic Rhinitis range are as follows:
Contains Montelukast 10mg + Levocetirizine 5mg tab


Montelukast
It is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast is a CysLT1 antagonist; it blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation.

Levocetirizine
It is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the R-enantiomer of the cetirizine racemate. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever.

Pharmacokinetic Data
Montelukast
Levocetirizine
Bioavaibility
63 to73 %
High
Protein Binding
99 %
90 %
Metabolism
Hepatic
Hepatic
Half Life
2.7 to 5.5 hours
6 to 10 hours
Excretion
Biliary
Renal & Fecal
 
Indications
  • Prophylaxis & Treatment of chronic asthma
  • Relief of symptoms of allergic rhinitis
  • Relief of symptoms of perennial allergic rhinitis
 
Dose
  • Adults (> 15 years) Numont™ tab once daily