Contains Ondansetron 2mg / tsp. Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic (to treat nausea and vomiting), often following chemotherapy. It affects both peripheral and central nerves. Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone.
Pharmacokinetic Data
Bioavaibility
:
~60 %
Protein Binding
:
70 to 76 %
Metabolism
:
Hepatic
Half Life
:
5 to 7 hours
Excretion
:
Renal
Indications
-
Nausea and Vomiting induced by Cytotoxic chemotherapy and radiotherapy
-
Prevention of post- operative nausea-vomiting
Dose
Related to Age of Child