DDD

Active Ingredients
  • CHOLECALCIFEROL
  • Strength
    60,000 I.U.
    Dosage Form
    Sachets
    Retail Pack
    1 gm
    Contain Cholecalciferol 60,000 I.U. Vitamin D is a group of fat-soluble secosteroids responsible for intestinal absorption of calcium and phosphate. vitamin D is unique because it can be ingested as cholecalciferol.

    In the liver vitamin D is converted to calcidiol, which is also known as calcifediol (INN), 25-hydroxycholecalciferol, or 25-hydroxyvitamin D—abbreviated 25(OH)D; and which is the specific vitamin D metabolite that is measured in serum to determine a person’s vitamin D status. Part of the calcidiol is converted by the kidneys to calcitriol, the biologically active form of vitamin D. Calcitriol circulates as a hormone in the blood, regulating the concentration of calcium and phosphate in the bloodstream and promoting the healthy growth and remodeling of bone. Calcidiol is also converted to calcitriol outside of the kidneys for other purposes, such as the proliferation, differentiation and apoptosis of cells; calcitriol also affects neuromuscular and inflammation.

    Pharmacokinetic Data
    It is absorbed well from the intestines in the presence of bile-salts. Absorption of D3 is better than D2. It is bound to a specific alpha-globulin in the circulation and is stored mainly in the adipose tissue for many months. It is hydroxylated in the liver and the metabolites are mainly excreted in the bile.

     
    Indications
    • Osteomalacia
    • Renal Osteodystrophy
    • Hypophosphatemia
    • PsoriasisMalabsorption states or Liver Diseases
    • Hypoparathyroidism
    • Pregnancy & Lactation
    Dose
  • Autoimmmune Disease ( 1 Sachets of DDD Weekly for 2 months & then monthly for 6 months)
  • Osteoporosis ( 1 Sachets of DDD weekly for 3 months)
  • Osteomalacia & Rickets (1 Sachets of DDD daily for 10 days)
  • Low back pain & joint pain ( 1 Sachets of DDD weekly for 8 to 12 weeks then 1 Sachets monthly)
  • Pregnancy & Lactation ( 1 Sachets of DDD in 4th ,7th , 8th month & 15 days interval in Lactation)
  • Cardiovascular Risk & Diabetes ( 1 Sachets of DDD every 15 days)