NUMONT

Active Ingredients
  • MONTELUKAST
  • LEVOCETIRIZINE
  • Strength
    10mg+5mg
    Dosage Form
    Tablets
    Retail Pack
    1x10 strip
    Contains Montelukast 10mg + Levocetirizine 5mg tab


    Montelukast
    It is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. It is usually administered orally. Montelukast is a CysLT1 antagonist; it blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation.

    Levocetirizine
    It is a third-generation non-sedative antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is the active enantiomer of cetirizine. It is the R-enantiomer of the cetirizine racemate. Levocetirizine works by blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hay fever.

    Pharmacokinetic Data
    Montelukast
    Levocetirizine
    Bioavaibility
    63 to73 %
    High
    Protein Binding
    99 %
    90 %
    Metabolism
    Hepatic
    Hepatic
    Half Life
    2.7 to 5.5 hours
    6 to 10 hours
    Excretion
    Biliary
    Renal & Fecal
     
    Indications
    • Prophylaxis & Treatment of chronic asthma
    • Relief of symptoms of allergic rhinitis
    • Relief of symptoms of perennial allergic rhinitis
     
    Dose
  • Adults (> 15 years) Numont™ tab once daily