RABEVIN-20

Active Ingredients
  • RABEPRAZOLE SODIUM
  • Strength
    20mg
    Dosage Form
    Tablets
    Retail Pack
    1x10 strip
    Contains Rabeprazole sodium 20mg (Enteric coated) tab. Rabeprazole is an antiulcer drug in the class of proton pump inhibitors.
    Acid is produced naturally in your stomach to help you digest food and to kill bacteria. This acid is irritant so your body produces a natural mucous barrier which protects the lining of your stomach. In some people, this barrier breaks down allowing the acid to damage the stomach, causing inflammation, ulcers and other conditions. In other people there may be a problem with the muscular band at the top of the stomach that keeps the stomach tightly closed. This may allow the acid to escape and irritate the oesophagus. This is called ‘acid reflux’ and can cause heartburn and/or oesophagitis.

    Proton pump inhibitors such as rabeprazole stop cells in the lining of the stomach from producing too much acid. This helps to prevent ulcers from forming, or assists the healing process where damage has already occurred. By decreasing the amount of acid, they can also help to reduce the symptoms of acid reflux disease, such as heartburn.

    Pharmacokinetic Data
    Bioavaibility
    :
    52 %
    Metabolism
    :
    Non-enzymatic, partly Hepatic
    Half Life
    :
    1 to 1.5 hours
    Excretion
    :
    90 % Renal
     
    Indications
    • Gastric ulcers
    • Peptic ulsers
    • Hyperacidity/ Gastritis due to NSAIDs
    • Healing & Maintenance of Erosive or Ulcerative GERD
    • Treatment of pathological hypersecretory conditions (Zollinger-Ellison syndrome)
    • Helicobacter pylori eradication to reduce risk of duodenal ulcer recurrence
     
    Dose
  • Just Once a day Rabevin-20 in GERD, duodenal, gastric, peptic ulcers. (Therapy for 4 weeks to 8 weeks)
  • In triple therapy for Helicobacter pylori infection , Rabevin-20 was combined with either clarithromycin 500 mg and metronidazole 400 mg, or amoxicillin 1000 mg and clarithromycin 500 mg, or amoxicillin 1000 mg and metronidazole 400 mg each given orally twice a day for 7 days. These combinations provided eradication rates of 100%, 95%, and 90% respectively.
  • In Zollinger-Ellison syndrome, * Initial: 60 mg orally once a day, after the morning meal, **Maintenance: Doses up to 100 mg orally once a day or 60 mg orally twice a day have been administered. Patients have been treated continuously for up to one year.