Rabevin D

Active Ingredients
rabeprazole sodium + domperidone
Strength
20mg+30mg
Dosage Form
Tablet
Retail Pack
1x10 strip
Rabeprazole
Rabeprozole is a antiulcer drug in the class of proton pump inhibitor. It is used in short term treatment in healing and symptomatic relief of duodenal ulcer and erosive or ulcerative gastroesophageal reflux diseases (GERD). It also used in long term treatment of pathological hypersecretory conditions including zollinger-ellision syndrome.

Mechanism of action
rabeprazole is selective irreversible ppi. Rabeprazole suppresses gastric acid secretion by specific inhibition of the hydrogen potassium adenosine triphosphate (H+, K+, ATpase) enzyme system found at the secretory surface of parietal cells. It inhibits the final transport of hydrogen ion (via exchange with potassium ions) into the gastric lumen. Since the H+ K+ ATPase enzyme system is regarded as the acid (proton) pump of gastric mucosa. Rabeprazole is known as a gastric acid pump inhibitor. Rabeprazole does not have anticholinergic or histamine H2 receptor antagonist properties.

Domperidone
It is medication specific blocker of dopamine receptor. It is administered orally. Domperidone is given in order to relieve nausea & vomiting. It increases the transit the food through the stomach and to increases lactation by release prolactin.

Mechanism of action
domperidon is a peripheral dopamine (D2 & D3) receptor antagonist. It provides relief from nausea by blocking receptors at the chemoreceptor trigger zone (location in nervous system that registers nausea). It blocks dopamine receptors in the posterior pituitary gland increasing release of prolactin which in turn increase lactation.

Pharmacokinetic Data
Rabeprazole sodium
Domperidone
Bioavailability
52%
High
Metabolism
Mostly non enzymatic partly Hepatic
Hepatic and Intestinal
Protein Binding
96%
91-93%
Half life
1 to 1.5 hrs
7 hrs
Excretion
Renal 90%
Breast milk, Renal
 


Indications
  • Healing of duodenal ulcers
  • Gastric hyper-secretion
  • Gastro Esophageal reflux disease (GERD)
  • Heart burn symptoms
 


Dose
  • OD dose before meal.